Sebastian Caine is a brilliant yet arrogant scientist working on a top secret mission for the U.S. government -- to unlock the secret to human invisibility. After creating a serum that induces invisibility in laboratory animals, he disobeys Pentagon orders by trying the serum on himself. Though it works, the effects are irreversible. While his chief lieutenants Linda McKay and Matt Kensington try frantically to counteract the effect, Caine becomes increasingly intoxicated by his new found power. Not only do his latent megalomaniac tendencies begin to emerge, they get stronger the longer he remains invisible as he begins to perceive all efforts to cure him as a threat to his very existence.