To most people, Joe is a myth and a legend; a huge gorilla, a sacred guardian and defender of the natives of a small African village. To his only friend Jill, he is a protector and companion. Together they are the only family each has had since their respective mothers were killed by poachers 20 years ago. Now, when zoologist Gregg O'Hara, who is exploring the remote Pangani Mountains in Central Africa, comes upon the awesome 15-foot gorilla, he and Jill rescue the strong yet innocent creature from human predators by moving him into safety of a California animal conservancy. However, Joe is not safe for long. His notoriety makes him a target for an enemy from his past... a ruthless hunter who eager to steal Joe for his unique value on the endengered species black market. Feeling threatened and confused in his man-made confines, Joe finally escapes. As this powerful force of nature attempts to traverse the metropolis of Los Angeles, he leaves a trail of destruction and chaos in his wake.